The Colts trade Quenton Nelson to Seattle and DeForest Buckner to San Francisco, while the Giants, Bengals and Ravens face significant injuries.
The Giants name J.J. McCarthy their starter, Roger Goodell addresses the Jalen Hurts investigation, and Patriots injuries headline Week 7.
Caleb Williams moves closer to returning, Marvin Harrison Jr. will debut for Houston and Lamar Jackson remains day-to-day entering Week 6.
Mike Ditka passes away at 86, Lamar Jackson is ruled out, and the Eagles lose Saquon Barkley and DeVonta Smith for Sunday's London game.
Philadelphia trades Cam Jurgens to Baltimore, DeMeco Ryans takes over Houston's defense and Baker Mayfield misses Thursday Night Football.
O'Cyrus Torrence and Peter Skoronski land major extensions, Patrick Mahomes may skip the preseason and the Saints add veteran help.
